PDF Chapter 28, Hypophosphatasia

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Based on the consensus of panel members, this review provides guidance on the monitoring of patients with HPP during treatment with asfotase alfa, including recommendations for laboratory, efficacy, and safety assessments and the frequency with which these should be performed during the course of treatment. Recommended assessments are based on patient age and include regular monitoring of biochemistry, skeletal radiographs, respiratory function, growth, pain, mobility and motor function, and quality of life.

Because of the systemic presentation of HPP, a coordinated, multidisciplinary, team-based, patient-focused approach is recommended in the management of patients receiving asfotase alfa. Monitoring of efficacy and safety outcomes must be tailored to the individual patient, depending on medical history, clinical manifestations, availability of resources in the clinical setting, and the clinician's professional judgment.

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These authors contributed equally to the work as co-lead authors and senior author, respectively; the remaining authors are listed in alphabetical order to reflect their equal contributions. We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies. Download PDF Download. Author links open overlay panel Priya S.

Kishnani a 1 Eric T. Munns i j Mark E. Nunes k Howard M.

  • Wilde Vengeance?
  • Hypophosphatasia: A Systemic Skeletal Disorder Caused by Alkaline Phosphatase Deficiency?
  • Asfotase alfa for treating paediatric-onset hypophosphatasia!

Deals exclusively with bone development and diseases of children and each chapter is written by an expert in the field Fully referenced providing an appendix of usually difficult to find information on the investigation of pediatric bone disease and reference values Covers both the physiology of bone and mineral homeostasis in children and diseases in one book.

McKee, William G.

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Cole 3. Kronenberg 5. Potts, Thomas J.

Gardella 7. Arnaud, Marie B. Demay 9.

Kovacs Leonard, Laura K. Bachrach Martin, Noel Cameron Rimoin Glorieux Glorieux, David Rowe Pettifor Salusky, Katherine Wesseling Perry Shore, Frederick S. Powered by.


perinatal lethal hypophosphatasia: Topics by tanomedzioread.ml

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